Spinal cord injury (SCI) is a life-changing event, which can cause devastating loss of voluntary movement, but can also impact on bladder and bowel function. Many people living with a SCI rely on catheterisation to empty their bladder. Catheterisation can lead to recurrent urinary tract infections (rUTI) which may require oral or IV antibiotic treatment. Regular use of oral or IV antibiotics can lead to side effects including changes in gut microbiome and resistance. Instilling antibiotics directly into the bladder, may overcome some of the negative effects of oral/IV antibiotics for rUTI. The aim of this feasibility study was to investigate the tolerability and efficacy of intravesical gentamicin in preventing recurrent UTI in a patient cohort with SCI. We report the findings of the study on 20 SCI patients who reported more than 3 UTI per year and performed home-based instillations of intra-vesical gentamicin for a period of 12 weeks.