Dr Jean-Pierre Lin
Evelina London Children’s Hospital, Guy’s and St Thomas’ NHS Foundation Trust, King's Health Partner
Consultant Paediatric Neurologist / President, British Paediatric Neurology Association
Jean-Pierre Lin qualified in medicine in 1983 from Edinburgh University Medical School training initially in medicine, adult neurology and paediatrics. He obtained an Edinburgh University George Guthrie Research Fellowship (1990-4) leading to a PhD in physiology at Edinburgh University on ‘Motor Assessments in Cerebral Palsy’ under E Geoffrey Walsh, motor physiologist and J Keith Brown, paediatric neurologist.
In 1994 he received the American Academy of Cerebral Palsy and Developmental Medicine Richmond Paine Cerebral Palsy Award and was appointed Senior Registrar in Paediatric Neurology at Great Ormond Street Hospital for Children, becoming Consultant Paediatric Neurologist in 1996 at the Evelina London Children’s Hospital, Guy’s & St Thomas’ NHS FoundationTrust. He has developed many services for children with movement disorders, including the One Small Step Gait and Movement Laboratory; the Movement Therapy Clinics aimed particularly at delivering intramuscular botulinum toxin A injections for abnormal movements and postures. He leads the Complex Motor Disorders Assessment and Management Service (CMDS) 2006-present thanks to a New Services and Innovation Grant (G060708) from the Guy’s and St Thomas’ Charity from April 2007-9 to deliver Deep Brain Stimulation (DBS) for children with dystonia.
He is President of the British Paediatric Neurology Association (BPNA), and chairs the BPNA Movement Disorders Clinical-Research-Network an advisor to Dystona Europe, and on the board of the European Paediatric Neurology Society.
Advances in Deep Brain Stimulation Neuromodulation for Movement Disorders in Children
Movement disorders profoundly affect the lives of children, are often painful, interrupt sleep, sitting and daily care while reducing activity and participation in education, play and social interaction.
Medication and physical measures are often ineffective and adverse effects common. Deep brain stimulation (DBS) can profoundly reduce the impact of an increasingly recognized number of genetic movement disorders including dystonia (twisting and writhing postures and movements), chorea (dance-like rapid movements), myoclonus (lightning jerks) and tremors. A key area of clinical research is the effect of DBS neuromodulation on dystonia and chorea (also known as dyskinesia) in children with cerebral palsy (CP).
The benefits of DBS seem related to the proportion-of-life-lived with CP, indicating that early or very early DBS intervention may be most effective at a time when the developing brain’s ‘critical’ and ‘sensitive windows’ are still open to influence and particularly before the onset of permanent musculoskeletal deformity.
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